Current medical research and opinion
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Randomized Controlled Trial Multicenter Study Comparative Study
Duloxetine versus placebo in the treatment of major depressive disorder and associated painful physical symptoms: a replication study.
Painful physical symptoms are common in patients with major depressive disorder (MDD) and can negatively affect patient outcomes. Duloxetine has demonstrated efficacy in treating MDD and other certain painful conditions; this study specifically evaluated patients with both MDD and MDD-associated pain. ⋯ These results replicated findings supporting the efficacy and tolerability of duloxetine compared to placebo as treatment for depression and pain in patients with MDD and at least moderate pain associated with MDD.