Pancreas

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• Pancreas · Apr 2011

  Preprotachykinin-A gene deletion regulates hydrogen sulfide-induced toll-like receptor 4 signaling pathway in cerulein-treated pancreatic acinar cells.

  This study aimed to determine the effect of hydrogen sulfide (H2S) on Toll-like receptor 4 (TLR4)-mediated innate immune signaling in acute pancreatitis (AP) via substance P. ⋯ The present findings show for the first time that in AP, H2S may up-regulate the TLR4 pathway and NF-κB via substance P.

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