International clinical psychopharmacology
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Int Clin Psychopharmacol · Apr 1987
Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical TrialFluvoxamine and imipramine: results of a long-term controlled trial.
Following a multicentre double-blind controlled trial comparing the effects of fluvoxamine and imipramine in depressed inpatients (M. D. E.) 39 patients continued on longer term treatment with maintenance of double-blind conditions (17 on fluvoxamine, 22 on imipramine). ⋯ There were several significant differences in favour of fluvoxamine at the 20th week. The most common side-effects were hot flushes with imipramine and dizziness with fluvoxamine. Overall, despite the small number of patients, the results show a greater clinical tolerance to fluvoxamine than to imipramine.