International clinical psychopharmacology
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Int Clin Psychopharmacol · Apr 1987
Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical TrialFluvoxamine and imipramine: results of a long-term controlled trial.
Following a multicentre double-blind controlled trial comparing the effects of fluvoxamine and imipramine in depressed inpatients (M. D. E.) 39 patients continued on longer term treatment with maintenance of double-blind conditions (17 on fluvoxamine, 22 on imipramine). ⋯ There were several significant differences in favour of fluvoxamine at the 20th week. The most common side-effects were hot flushes with imipramine and dizziness with fluvoxamine. Overall, despite the small number of patients, the results show a greater clinical tolerance to fluvoxamine than to imipramine.
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Int Clin Psychopharmacol · Jul 1986
Adverse cognitive effects of general anaesthesia in young and elderly patients.
For many years, reports have appeared indicating cognitive deficits in elderly patients following anaesthesia. However, there is no general consensus of opinion concerning the putative relationship between these deficits and the anaesthetic process. In a prospective study, 85 patients undergoing elective surgery were assessed on a battery of standardized cognitive tests, 1 day before and 2 days after surgery. Analysis of results indicated that anaesthesia does produce post-operative cognitive deficits in both young and elderly patients, and a possible causative mechanism is discussed.