Metabolic brain disease
The most recent articles from:
March 2009
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Metabolic brain disease · Mar 2009
ReviewThe brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema.
Acute liver failure (ALF) is a condition with an unfavourable prognosis. Multiorgan failure and circulatory collapse are frequent causes of death, but cerebral edema and intracranial hypertension (ICH) are also common complications with a high risk of fatal outcome. ⋯ This review will focus on the effects of hyperammonemia on neurotransmission, mitochondrial function, oxidative stress, inflammation and regulation of cerebral blood flow. Finally, potential therapeutic targets and future perspectives are briefly discussed.