Metabolic brain disease
The most recent articles from:
June 2010
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Metabolic brain disease · Jun 2010
Case ReportsGeneralized seizures aggravated by levetiracetam in an adult patient with phenylketonuria.
Phenylketonuria (PKU) is one of the most common inherited metabolic disorders, which is characterized by excessive accumulation of phenylalanine (Phe) in tissues. Generalized seizures occur in 25% of the patients. ⋯ Here we report an adult patient who developed generalized seizures later in life, despite strict dietary control, and whose seizures were aggravated by levetiracetam (LEV). Convulsions ceased after discontinuation of LEV and the patient has been seizure free on topiramate 125 mg/day.