Journal of critical care
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Journal of critical care · Jun 2009
Vascular endothelial growth factor receptor and coreceptor expression in human acute respiratory distress syndrome.
Acute respiratory distress syndrome (ARDS) is characterized by the development of noncardiogenic pulmonary edema, which has been related to the bioactivity of vascular endothelial growth factor (VEGF). Vascular endothelial growth factor receptors and coreceptors regulate this bioactivity. We hypothesized VEGF receptors 1 and 2 (VEGFR1, VEGFR2) and coreceptor neuropilin-1 (NRP-1) would be expressed in human lung tissue with a significant change in expression in ARDS lung. ⋯ Differential temporal VEGFR1, VEGFR2, and NRP-1 up-regulation occurs in human ARDS, providing evidence of further functional regulation of VEGF bioactivity via VEGFR2 consistent with a protective role for VEGF in lung injury recovery. The mechanisms behind these observations remain to be clarified.
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Journal of critical care · Jun 2009
Outcome of early intensive care unit patients readmitted in the same hospitalization.
The aim of the study was to evaluate factors associated with early readmission to the intensive care unit (ICU) during the same hospitalization and factors associated with adverse outcomes. ⋯ Patients with respiratory and cardiovascular diseases are at greatest risk for early ICU readmission. Better patient assessment and knowledge of factors associated with early readmission may contribute to reduced mortality.
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Journal of critical care · Jun 2009
ReviewLow-molecular-weight heparin thromboprophylaxis in medical-surgical critically ill patients: a systematic review.
The study aimed to systematically review the effect of low-molecular-weight heparin (LMWH) thromboprophylaxis in medical-surgical critically ill patients in the intensive care unit. ⋯ Low-molecular-weight heparin may be effective for thromboprophylaxis in medical-surgical critically ill patients, but no trials have compared LMWH against an alternative active strategy; thus, LMWH cannot be recommended routinely. Trials testing LMWH thromboprophylaxis are required, which examine patient-important end points such as the incidence and clinical consequences of VTE, bleeding, heparin-induced thrombocytopenia, and mortality.
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Journal of critical care · Jun 2009
ReviewThe intensive care unit work environment: current challenges and recommendations for the future.
The need for critical care services has grown substantially in the last decade in most of the G8 nations. This increasing demand has accentuated an already existing shortage of trained critical care professionals. Recent studies argue that difficulty in recruiting an appropriate workforce relates to a shortage of graduating professionals and unhealthy work environments in which critical care professionals must work. ⋯ This narrative review summarizes existing literature and experiences about the key work environment challenges reported within the critical care context and suggests best practices-implemented in hospitals or suggested by professional associations-which can be an initial step in enhancing patient care and professional recruitment and retention in our intensive care units, with particular emphasis on the recruitment and retention of an appropriately trained and satisfied workforce. The experiences are categorized for the physical, emotional, and professional environments. A case study is appended to enhance understanding of the magnitude and some of the proposed remedies of these experiences.
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Journal of critical care · Jun 2009
ReviewManagement of venous thromboembolism in the intensive care unit.
Venous thromboembolism, manifested as either deep venous thrombosis or pulmonary embolism (PE), is a major cause of morbidity and mortality in patients admitted to the intensive care unit. Clinically, PE may present as massive thromboembolism associated with cardiogenic shock or may be asymptomatic, as may occur with anatomically small emboli without hemodynamic or respiratory compromise. The management of venous thromboembolism in the critically ill patient can be exceedingly complex. ⋯ Prevention of recurrent PE is accomplished with anticoagulation and/or placement of an inferior vena cava filter. Definitive therapy involves thrombolysis and surgical or catheter embolectomy. Fluid and vasoactive therapy with norepinephrine may be indicated for refractory hypotension in patients with massive PE.