Journal of critical care
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Journal of critical care · Aug 2019
Comparative Study Observational StudyEvaluation of MR-proANP and copeptin for sepsis diagnosis after burn injury.
The significance of the validated biomarkers of sepsis Mid-regional pro-atrial natriuretic peptide (MR-proANP) and copeptin have not been tested in a burn injury setting. ⋯ Burn injury itself maybe associated with copeptin and to a lesser degree MR-proANP level increases. Subsequent increases in MR-proANP may be considered diagnostic for sepsis but demonstrated no advantages over PCT. The role of copeptin remains inappropriate for diagnosing sepsis after burn injury (ClinicalTrials.gov number, NCT01055587).
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Journal of critical care · Aug 2019
Comparative Study Observational StudyAnti-Xa activity by weight in critically ill patients receiving unfractionated heparin for venous thromboembolism prophylaxis.
This study compared anti-Xa activity in critically ill patients receiving UFH for VTE prophylaxis between two weight groups (<100 kg vs ≥100 kg). ⋯ Though only one-third of patients ≥100 kg had peak anti-Xa activity within goal range, no significant difference was found between the weight groups. Additional prospective studies with adequate sample sizes are warranted to further investigate appropriate weight-based dosing of UFH in critically ill patients.
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Journal of critical care · Aug 2019
Review Meta AnalysisEffects of post-ICU follow-up on subject outcomes: A systematic review and meta-analysis.
The present systematic review and meta-analysis aimed to synthesize data on subject outcomes associated with post-ICU follow-up. ⋯ Post-ICU follow-up may improve depression symptoms and mental health-related quality of life in the short term for models focusing on physical therapy and PTSD symptoms in the medium term for models focusing on psychological or medical management interventions.
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Journal of critical care · Aug 2019
Review Meta AnalysisConstipation, diarrhea, and prophylactic laxative bowel regimens in the critically ill: A systematic review and meta-analysis.
Prophylactic laxative bowel regimens may prevent constipation in enterally-fed critically ill patients. However, their use may also increase diarrhea. We performed a systematic review to: 1. Explore the epidemiology of constipation and/or diarrhea in critically ill patients; and 2. Appraise trials evaluating prophylactic laxative bowel regimens. ⋯ Constipation and diarrhea occur frequently in the critically ill but data evaluating prophylactic laxative bowel regimens in such patients are sparse and do not support their use.