Journal of critical care
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Journal of critical care · Jun 2020
Multicenter Study Observational StudyA new simplified and accurate sa-SOFA score.
Several remarks have been raised regarding the variables and cut-points used in the Sequential Organ Failure Assessment (SOFA) score. This study revisited the SOFA score and created a new simplified and accurate sa-SOFA score. ⋯ Keeping the conventional SOFA dimension variables, the new sa-SOFA proved to be simpler and more accurate in predicting 28-day mortality.
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Journal of critical care · Jun 2020
Multicenter Study Observational StudyProphylactic use of platelets in critically ill patients with thrombocytopaenia: A retrospective two-centre observational study.
We report the use and effect of prophylactic platelet transfusions in critically ill thrombocytopaenic patients, comparing patients with or without bone marrow failure as a cause of thrombocytopaenia. ⋯ Platelet transfusions were given at a higher median platelet count than suggested by guidelines. Patients with bone marrow failure were transfused at a lower threshold and experienced a smaller increment in platelet count when compared to patients without marrow failure.
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Journal of critical care · Jun 2020
Multicenter StudyImproving medication safety in the Intensive Care by identifying relevant drug-drug interactions - Results of a multicenter Delphi study.
Drug-drug interactions (DDIs) may cause adverse outcomes in patients admitted to the Intensive Care Unit (ICU). Computerized decision support systems (CDSSs) may help prevent DDIs by timely showing relevant warning alerts, but knowledge on which DDIs are clinically relevant in the ICU setting is limited. Therefore, the purpose of this study was to identify DDIs relevant for the ICU. ⋯ A list of clinically relevant DDIs for the ICU setting was established on a national level. The clinical value of CDSSs for medication safety could be improved by focusing on the identified clinically relevant DDIs, thereby avoiding alert fatigue.
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Journal of critical care · Jun 2020
Observational StudyPharmacogenomic response of low dose haloperidol in critically ill adults with delirium.
To characterize the pharmacogenomic response of low-dose haloperidol for delirium treatment in critically ill adults. ⋯ This pilot study, the first to evaluate the pharmacogenomic response of low-dose haloperidol when used to treat delirium in the ICU, suggests CYP2D6/CYP3A4 metabolizer status does not affect the serum haloperidol concentrations.
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Journal of critical care · Jun 2020
Observational StudyImpact on ICU mortality of moderate alcohol consumption in patients admitted with infection.
Alcohol dependence is associated with poor prognosis in the intensive care unit (ICU), but it remains uncertain whether moderate alcohol consumption negatively affects the prognosis of critically ill patients admitted with infection. ⋯ Alcohol consumption between 100 and 350 g/week was independently associated with mortality at day 28. Our results suggest that in critically ill patients admitted with infection, moderate alcohol consumption is associated with a poorer prognosis.