Journal of critical care
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Journal of critical care · Apr 2016
Randomized Controlled TrialThe effect of framing on surrogate optimism bias: A simulation study.
To explore the effect of emotion priming and physician communication behaviors on optimism bias. ⋯ Framing of CPR choice during code status conversations may influence surrogates' optimism bias.
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Journal of critical care · Apr 2016
Randomized Controlled TrialMarkers of endothelial damage and coagulation impairment in patients with severe sepsis resuscitated with hydroxyethyl starch 130/0.42 vs Ringer acetate.
The Scandinavian Starch for Severe Sepsis/Septic Shock (6S) trial showed increased mortality in patients resuscitated with hydroxyethyl starch 130/0.42 (HES) vs Ringer acetate. Different effects of the fluids on the endothelium may have contributed to the observed outcome. We aimed to investigate associations between HES vs Ringer and changes in plasma biomarkers reflecting endothelial damage and coagulation impairment. ⋯ Resuscitation with HES vs Ringer decreased early endothelial damage. Although this finding should be interpreted with caution, it indicates that the increased mortality observed with HES in the 6S trial may not be explained by endothelial damage and it emphasizes the challenge of using surrogate markers as outcome.
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Journal of critical care · Feb 2016
Randomized Controlled TrialPrevalence, risk factors, and outcomes associated with physical restraint use in mechanically ventilated adults.
The purpose was to describe characteristics and outcomes of restrained and nonrestrained patients enrolled in a randomized trial of protocolized sedation compared with protocolized sedation plus daily sedation interruption and to identify patient and treatment factors associated with physical restraint. ⋯ Physical restraint was common in mechanically ventilated adults managed with a sedation protocol. Restrained patients received more opioids and benzodiazepines. Except for alcohol use, patient characteristics and treatment factors did not predict restraint use.
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Journal of critical care · Feb 2016
Randomized Controlled TrialEffect of omega-3 on hepatic regeneration in adult living donors undergoing hepatic resections for liver transplantation: A randomized controlled trial.
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have been shown to improve liver regeneration in experimental models. Aim was to evaluate the effects of ω-3 PUFAs on hepatic regeneration in adult living donors undergoing partial hepatectomy for liver transplantation (LDLT). ⋯ Omega-3 polyunsaturated fatty acids effectively promoted liver regeneration and functional recovery following portal hypertension in the setting of LDLT.
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Journal of critical care · Dec 2015
Randomized Controlled Trial Multicenter StudyImpact of endotracheal intubation on septic shock outcome: A post hoc analysis of the SEPSISPAM trial.
The objective of the study to is to determine the characteristics associated with endotracheal intubation in septic shock patients. ⋯ Practices regarding the place of endotracheal intubation in septic shock may impact outcome.