Journal of critical care
-
Journal of critical care · Apr 2017
Review Meta AnalysisDexmedetomidine vs propofol sedation reduces delirium in patients after cardiac surgery: A meta-analysis with trial sequential analysis of randomized controlled trials.
It is uncertain whether dexmedetomidine is better than propofol for sedation in postcardiac surgery patients. The purpose of this meta-analysis was to compare the effects of dexmedetomidine and propofol sedation on outcomes in adult patients after cardiac surgery. ⋯ Dexmedetomidine sedation could reduce postoperative delirium and was associated with shorter length of intubation, but might increase bradycardia in patients after cardiac surgery compared with propofol.
-
Journal of critical care · Apr 2017
Review Meta AnalysisImpact of transfusion on stroke after cardiovascular interventions: Meta-analysis of comparative studies.
To evaluate the impact of transfusion on the development of stroke after cardiovascular interventions. ⋯ The present meta-analysis is registered in PROSPERO, code CRD42016046426.
-
Journal of critical care · Apr 2017
Review Meta AnalysisThe effect of early goal-directed therapy for treatment of severe sepsis or septic shock: A systemic review and meta-analysis.
To assess the effects of early goal-directed therapy (EGDT) on reducing mortality compared with conventional management of severe sepsis or septic shock. ⋯ This meta-analysis was heavily influenced by the recent addition of the trio of trials published after 2014. The results of the recent trio of trials may be biased due to methodological issues. This includes lack of blinding by incorporating similar diagnostic and therapeutic interventions as the original EGDT trial.
-
Journal of critical care · Feb 2017
Meta AnalysisThe effect of vasoactive drugs on mortality in patients with severe sepsis and septic shock. A network meta-analysis of randomized trials.
Inotropes and vasopressors are cornerstone of therapy in septic shock, but search for the best agent is ongoing. We aimed to determine which vasoactive drug is associated with the best survival. ⋯ Among several regimens for pharmacological cardiovascular support in septic patients, regimens based on inodilators have the highest probability of improve survival.
-
Journal of critical care · Feb 2017
Review Meta AnalysisRole of statins in delirium prevention in critical ill and cardiac surgery patients: A systematic review and meta-analysis.
The data evaluating the role of statins in delirium prevention in the intensive care unit are conflicting and limited. ⋯ In critically ill and cardiac surgery patients, this meta-analysis did not show a benefit with statin therapy in the prevention of delirium.