Journal of critical care
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Journal of critical care · Jun 2019
Multicenter Study Observational StudyHuman atrial natriuretic peptide for acute kidney injury in adult critically ill patients: A multicenter prospective observational study.
Acute kidney injury (AKI) is common in the intensive care unit (ICU). Selected clinical studies have implied human atrial natriuretic peptide (hANP) improves renal function; however, the treatment effects for AKI are unclear. ⋯ In critically ill patients with AKI, the treatment effect of hANP was not evident on dialysis-free survival in the ICU.
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Journal of critical care · Jun 2019
Multicenter Study Observational StudyPersistently high circulating tissue inhibitor of matrix metalloproteinase-1 levels in non-survivor brain trauma injury patients.
Previously, higher circulating levels of matrix metalloproteinase (MMP)-9 and tissue inhibitor matrix metalloproteinases (TIMP)-1 were reported in the first hours after TBI in blood samples from patients with poor prognosis. Thus, the objectives of this study were to determine whether MMP-9 and TIMP-1 levels during the first week of a severe TBI could be used as biomarker predictive of mortality. ⋯ The most relevant new findings of our study were that TIMP-1 levels during the first week of a severe TBI were higher in non-surviving than in surviving patients and that could be used as biomarker predictive of mortality.
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Journal of critical care · Jun 2019
Multicenter Study Observational StudyEpidemiology and clinical outcomes of invasive mould infections in Indian intensive care units (FISF study).
Due to limited data on invasive mould infections (IMIs) in the intensive care units (ICUs) of developing countries, we ascertain epidemiology and management of IMIs at 11 ICUs across India. ⋯ The study highlights the distinct epidemiology of IMIs in India ICUs with high burden, new susceptible patient groups and considerable number of non-Aspergillus mould infections. [clinicaltrials.gov: NCT02683642].
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Journal of critical care · Jun 2019
Randomized Controlled TrialThe effect of direct hemoperfusion with polymyxin B immobilized cartridge on meropenem in critically ill patients requiring renal support.
To evaluate the effect of direct hemoperfusion with polymyxin B immobilized cartridge (DHP-PMX) on meropenem pharmacokinetics in critically ill patients with sepsis requiring continuous venovenous hemofiltration (CVVH). ⋯ No significant effect of DHP-PMX on meropenem pharmacokinetics was observed among severe sepsis/septic shock patients during CVVH treatment.
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Journal of critical care · Jun 2019
Physical impairment and perceived general health preceding critical illness is predictive of survival.
We hypothesized that item response based assessment of physical reserve preceding ICU admission is a predictor of survival. ⋯ Physical reserve as assessed by ALDS and perceived general health, preceding ICU admission is predictive of mortality. Obtaining patient's physical reserve or pre-existing perceived general health should be part of routine assessment whether a patient may benefit from ICU admission.