Journal of critical care
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Journal of critical care · Aug 2019
Multicenter StudyEpidemiology and outcomes of source control procedures in critically ill patients with intra-abdominal infection.
To describe the characteristics and procedural outcomes of source control interventions among Intensive Care Unit (ICU) patients with severe intra-abdominal-infection (IAI). ⋯ Approximately half of ICU patients with IAI require more than one intervention, yet successful source control is eventually achieved in a majority of cases.
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Journal of critical care · Aug 2019
Comparative Study Observational StudyEarly target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients: A prospective observational study.
To evaluate target attainment of empirically dosed continuous infusion piperacillin/tazobactam (TZP) and meropenem (MER) in critically ill patients. ⋯ Target attainment of empiric antibiotic therapy in critically ill patients was low (37%) for TZP and moderate (75%) for MER, despite the use of a loading dose and despite optimization of the mode of infusion.
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Journal of critical care · Aug 2019
Observational StudyInfluence of systemic hemodynamics on microcirculation during sepsis.
During sepsis, improvement of hemodynamic may not be related to improvement of microcirculation. The aim of this study was to investigate influence of systemic circulation on microcirculation in septic ICU patients. ⋯ DAP was the only independent determinant of resStO2 in septic patients. Fluid challenges may improve microcirculation. CVP did not influence resStO2.
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Journal of critical care · Aug 2019
Observational StudyThe incidence, characteristics, outcomes and associations of small short-term point-of-care creatinine increases in critically ill patients.
We assessed the incidence, characteristics, outcomes and associations of small, short-term point-of-care creatinine increases in critically ill patients. ⋯ Small, short-term point-of-care creatinine increase episodes are common. They are associated with illness severity, occur early, precede AKI by 10 h and are sensitive rather than specific markers of AKI.
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Journal of critical care · Aug 2019
Systemic response of coated-platelet and peripheral blood inflammatory cell indices after aneurysmal subarachnoid hemorrhage and long-term clinical outcome.
Post-hemorrhage period after aneurysmal subarachnoid hemorrhage (aSAH) has several systemic manifestations including prothrombotic and pro-inflammatory states. Inter-relationship between these states using established/routine laboratory biomarkers and its long-term effect on clinical outcome is not well-defined. ⋯ Coated-platelet rise after aSAH is associated with adverse long-term clinical outcome. NLR and PLR trends show an early immune-depressed state after aSAH.