Journal of critical care
The most recent articles from:
J Crit Care
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Journal of critical care · Oct 2017
ReviewInterventions affecting mortality in critically ill and perioperative patients: A systematic review of contemporary trials.
Confounders in randomized controlled trials (RCTs) reporting significant effects on mortality in critically ill patients using non-surgical techniques have not been systematically explored. We aimed to identify factors unrelated to the reported intervention that might have affected the findings and robustness of such trials. ⋯ These observations imply that major systematic biases exist and affect trial findings irrespective of the intervention being studied.