Journal of critical care
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Journal of critical care · Oct 2017
Review Meta AnalysisSystematic review and meta-analysis of renal replacement therapy modalities for acute kidney injury in the intensive care unit.
To compare clinical outcomes among critically ill adults with acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT), intermittent hemodialysis (IHD) or sustained low efficiency dialysis (SLED). ⋯ We did not find a definitive advantage for any RRT modality on short-term patient or kidney survival. Well-designed, adequately-powered trials are needed to better define the role of RRT modalities for treatment of critically ill patients with AKI.
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Journal of critical care · Oct 2017
Review Meta AnalysisTherapeutic effect of beta-blocker in patients with traumatic brain injury: A systematic review and meta-analysis.
β-Blocker exposure has been shown to reduce mortality in traumatic brain injury (TBI); however, the efficacy of β-blockers remains inconclusive. Therefore, a meta-analysis was conducted in this paper to evaluate the safety and efficacy of β-blocker therapy on patients with TBI. ⋯ The meta-analysis demonstrates that β-blockers are effective in lowering mortality in patients with TBI. However, β-blocker therapy has markedly increased the infection rate and requires a longer period of ventilator support, intensive care management as well as length of stay.
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Journal of critical care · Oct 2017
Multicenter Study Observational StudyBiomarkers kinetics in the assessment of ventilator-associated pneumonia response to antibiotics - results from the BioVAP study.
Our aim was to evaluate the role of biomarker kinetics in the assessment of ventilator-associated pneumonia (VAP) response to antibiotics. ⋯ C-reactive protein kinetics can be used to identify VAP patients with poor outcome as soon as four days after the initiation of treatment. (Trial registration - NCT02078999; registered 3 August 2012).