Journal of critical care
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Journal of critical care · Dec 2017
Multicenter StudyA multifactor model for predicting mortality in critically ill patients: A multicenter prospective cohort study.
The objective of this study was to develop a model using a combination of routine clinical variables to predict mortality in critically ill patients. ⋯ The developed multifactor model can be used to effectively predict mortality in critically ill patients at ICU admission.
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Journal of critical care · Oct 2017
Multicenter StudyPediatric intermediate care and pediatric intensive care units: PICU metrics and an analysis of patients that use both.
To examine how intermediate care units (IMCUs) are used in relation to pediatric intensive care units (PICUs), characterize PICU patients that utilize IMCUs, and estimate the impact of IMCUs on PICU metrics. ⋯ There was no association between having an IMCU and most measures of PICU efficiency. At hospitals with an IMCU, patients spent more time in the PICU once they were cleared for discharge. Other ways that IMCUs might affect PICU efficiency or particular patient populations should be investigated.
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Journal of critical care · Oct 2017
Multicenter Study Observational StudyNon-survivor septic patients have persistently higher serum sCD40L levels than survivors.
Soluble CD40 ligand (sCD40L) is a protein with proinflammatory and prothrombotic effects. Previously we found higher circulating sCD40L levels in non-survivor than in survivor patients at sepsis diagnosis. Now some questions arise such as how are serum sCD40L levels during the first week of severe sepsis?, is there an association between serum sCD40L levels during the first week and mortality?, and serum sCD40L levels during the first week could be used as sepsis mortality biomarker?. This study was developed to answer these asks. ⋯ The novel findings of our study were that there were higher serum sCD40L levels persistently during the first week in non-survivor than in survivor patients, that there is an association between serum sCD40L levels during the first week and sepsis mortality, and that serum sCD40L levels during the first week could be used as sepsis mortality biomarker.
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Journal of critical care · Oct 2017
Multicenter Study Observational StudyBiomarkers kinetics in the assessment of ventilator-associated pneumonia response to antibiotics - results from the BioVAP study.
Our aim was to evaluate the role of biomarker kinetics in the assessment of ventilator-associated pneumonia (VAP) response to antibiotics. ⋯ C-reactive protein kinetics can be used to identify VAP patients with poor outcome as soon as four days after the initiation of treatment. (Trial registration - NCT02078999; registered 3 August 2012).
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Journal of critical care · Oct 2017
Multicenter StudyHypoalbuminemia, systemic inflammatory response syndrome, and functional outcome in intracerebral hemorrhage.
Hypoalbuminemia and systemic inflammatory response syndrome (SIRS) are reported in critically-ill patients, but their relationship is unclear. We sought to determine the association of admission serum albumin and SIRS with outcomes in patients with intracerebral hemorrhage (ICH). ⋯ In patients with ICH, hypoalbuminemia is strongly associated with SIRS. SIRS, but not hypoalbuminemia, predicts poor outcome at discharge. Recognizing and managing SIRS early may prevent death or disability in ICH patients.