Journal of critical care
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Journal of critical care · Dec 2016
Admission plasma levels of the neuronal injury marker neuron-specific enolase are associated with mortality and delirium in sepsis.
Neuron-specific enolase (NSE) concentrations are prognostic following traumatic and anoxic brain injury and may provide a method to quantify neuronal injury in other populations. We determined the association of admission plasma NSE concentrations with mortality and delirium in critically ill septic patients. ⋯ Higher plasma NSE concentrations were associated with mortality and delirium in critically ill septic patients, suggesting that NSE may have utility as a marker of neuronal injury in sepsis.
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Journal of critical care · Dec 2016
Information handoff and outcomes of critically ill patients transferred between hospitals.
Patients transferred between hospitals are at high risk of adverse events and mortality. This study aims to identify which components of the transfer handoff process are important predictors of adverse events and mortality. ⋯ Documentation completeness is associated with improved outcomes and resource utilization in patients transferred between hospitals.
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Journal of critical care · Dec 2016
Immortal time bias in observational studies of time-to-event outcomes.
The purpose of the study is to show, through simulation and example, the magnitude and direction of immortal time bias when an inappropriate analysis is used. ⋯ To minimize the risk of immortal time bias in observational studies of survival outcomes, we strongly suggest time-dependent exposures be included as time-dependent variables in hazard-based analyses.
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Journal of critical care · Dec 2016
Comment LetterResponse to the letter by Dr Sébastien Champion regarding the study "Can mortality due to circulatory failure in comatose out-of-hospital cardiac arrest patients be predicted on admission? A study in a retrospective derivation cohort validated in a prospective cohort".