Journal of critical care
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Journal of critical care · Dec 2012
Multiprofessional survey of protocol use in the intensive care unit.
To date, there has been no large multicenter, multiprofessional evaluation of protocol and guideline use in the intensive care unit (ICU). The primary purpose of this study was to describe national availability, development, implementation, and assessment of protocols in ICUs. A secondary objective was to compare perceived utility by ease of use, patient safety, cost containment, and compliance of protocols between nurses, physicians, and pharmacists. ⋯ The types of protocols available appear to be those assisting with management of high-alert medications. Overcoming the perceived barriers of protocol use within ICUs requires personnel for development and physician support. A better protocol review process may be necessary to assure optimal content, desired outcomes, and consistency with Institute for Safe Medication Practices guidelines.
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Journal of critical care · Dec 2012
Being overweight or obese is associated with decreased mortality in critically ill patients: a retrospective analysis of a large regional Italian multicenter cohort.
To describe the epidemiology of obesity in a large cohort of intensive care unit (ICU) patients and study its impact on outcomes. ⋯ In this cohort, overweight and obese patients had a reduced risk of ICU death. Being underweight or morbidly obese was associated with an increased risk of death in some subgroups of patients.
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Journal of critical care · Dec 2012
Clinical TrialNonpharmacologic approach to minimizing shivering during surface cooling: a proof of principle study.
This study had 2 objectives: (1) to quantify the metabolic response to physical cooling in febrile patients with systemic inflammatory response syndrome (SIRS) and (2) to provide proof for the hypothesis that the efficiency of external cooling and the subsequent shivering response are influenced by site and temperature of surface cooling pads. ⋯ Our results identify the hazards of surface cooling in febrile critically ill patients and support the concept that optimization of cooling pad temperature and position may improve cooling efficiency and reduce shivering.
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Journal of critical care · Dec 2012
Beneficial role of endogenous immunoglobulin subclasses and isotypes in septic shock.
There is increasing evidence on the relationship between endogenously produced immunoglobulins and the clinical outcome in septic shock (SS). ⋯ Our study evidenced that, in addition to IgG1, other major endogenous immunoglobulins isotypes and subclasses seem to play a beneficial role in SS.
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Journal of critical care · Dec 2012
Response to a bolus of conivaptan in patients with acute hyponatremia after brain injury.
The aim of the study was to analyze the response to the vasopressin-receptor antagonist conivaptan in a large cohort of brain-injured patients with acute hyponatremia. ⋯ Conivaptan given as a bolus can effectively treat acute hyponatremia in brain-injured patients.