Journal of critical care
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Journal of critical care · Oct 2024
Observational StudyHigh PEEP/low FiO2 ventilation is associated with lower mortality in COVID-19.
The positive end-expiratory pressure (PEEP) strategy in patients with coronavirus 2019 (COVID-19) acute respiratory distress syndrome (ARDS) remains debated. Most studies originate from the initial waves of the pandemic. Here we aimed to assess the impact of high PEEP/low FiO2 ventilation on outcomes during the second wave in the Netherlands. ⋯ High PEEP ventilation was associated with improved ICU survival in patients with COVID-ARDS.
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Journal of critical care · Oct 2024
Review Meta AnalysisOutcomes of extracorporeal blood purification with oXiris® membrane in critically ill patients: A systematic review and meta-analysis.
To evaluate the efficacy of the novel oXiris® membrane in critically ill adult patients. ⋯ In critically ill patients, the use of oXiris® membrane was associated with reduced overall mortality, norepinephrine dosage, CRP, IL-6, lactate levels, along with improved organ function. However, the certainty of evidence was very low, necessitating high-quality RCTs to further evaluate its efficacy in this population.
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Journal of critical care · Oct 2024
Prophylactic versus restrictive platelet transfusion strategy in patients with haematological malignancies in the ICU setting, a propensity-score analysis.
Prophylactic platelet transfusions (PT) aim to reduce bleeding. We assessed whether restrictive PT compared to prophylactic strategy could apply in ICU. ⋯ A restrictive PT strategy appears feasible in the ICU.
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Journal of critical care · Oct 2024
Effectiveness of early high-flow nasal oxygen therapy after extubation of patients in the intensive care unit.
This study aimed to evaluate the impact of early high-flow nasal oxygen (HFNO) therapy initiation using a pre-determined respiratory rate‑oxygenation (ROX) index on reducing reintubation rates and duration of intensive care unit (ICU) stay in post-extubated patients. ⋯ Early initiation of HFNO guided by the ROX index threshold post-extubation in patients admitted to ICU is associated with reduced reintubation rates and shorter ICU stays.