Movement disorders : official journal of the Movement Disorder Society
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Randomized Controlled Trial Clinical Trial
A pilot, double-blind, placebo-controlled trial of pregabalin (Lyrica) in the treatment of essential tremor.
We performed a pilot, double-blind, placebo-controlled, randomized trial to evaluate the efficacy and tolerability of pregabalin (PGB, Lyrica), an antiepileptic agent, in treating essential tremor (ET). Twenty two patients with ET were randomly assigned to receive PGB or placebo. PGB was initiated at 50 mg/day and was escalated by 75 mg/day every 4 days to a maximum dose of 600 mg/day. ⋯ PGB was fairly well tolerated, with about one-third of patients dropping out of the study because of adverse events. PGB provided significant improvements in accelerometry and in action tremor limb scores on the FTM. However, larger studies are needed to further evaluate the potential effect of PGB on ET.
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Letter Case Reports
Epileptic myoclonus as ciprofloxacin-associated adverse effect.