Movement disorders : official journal of the Movement Disorder Society
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Comparative Study
Comparison of subthalamic nucleus deep brain stimulation and Duodopa in the treatment of advanced Parkinson's disease.
Subthalamic nucleus deep brain stimulation (STN-DBS) and levodopa/carbidopa enteral (Duodopa) infusion are two effective therapeutic options for the treatment of advanced Parkinson's disease (PD). ⋯ STN-DBS and Duodopa showed a significant efficacy on motor symptoms, activities of daily living, and motor complications. The group of Duodopa-treated patients developed more procedure-related complications.
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Comparative Study
Instability of syllable repetition in Parkinson's disease--influence of levodopa and deep brain stimulation.
The aim of this study was to test the hypothesis of a fundamental impairment of vocal pace performance in Parkinson's disease (PD) based on a syllable repetition paradigm and the influence of levodopa and deep brain stimulation of the subthalamic nucleus (STN-DBS). Twenty-two PD patients under stable dopaminergic medication, 14 patients with STN-DBS, and 30 controls were tested. Participants had to repeat the syllable /pa/ in a steady pace. ⋯ COV was elevated in both PD subgroups. COV was not influenced by levodopa administration but showed a further deterioration under STN-DBS. The impaired syllable repetition capacity shows similarities to the patterns of more complex speech rhythm abnormalities in PD and therefore might share the same pathophysiology.