Advances in therapy
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Advances in therapy · Sep 2008
Randomized Controlled Trial Comparative StudyImpact of beta-blockers on sleep in patients with mild hypertension: a randomized trial between nebivolol and metoprolol.
Sleep is an innate and essential part of human life. Various aspects of sleep are negatively affected by beta-blockers. We compared the impact of two beta-blockers, metoprolol succinate (extended release) and nebivolol, on sleep quality in patients with stage 1 hypertension. ⋯ Nebivolol was associated with improved sleep (as assessed by the PSQI), whereas metoprolol was associated with a worsening of sleep characteristics.