Advances in therapy
-
Advances in therapy · Oct 2014
Preventive effect of intraoperative landiolol administration on atrial fibrillation after off-pump coronary artery bypass grafting.
Postoperative atrial fibrillation (AF) is a common complication of cardiac surgery that is associated with an increased incidence of other complications. This study evaluated the safety and efficacy of landiolol hydrochloride--an ultrashort-acting β1-selective blocker and highly regulated drug, positioned as a class 1 antiarrhythmic in Japan guidelines--for the prevention of AF after off-pump coronary artery bypass grafting (CABG). ⋯ Intraoperative and perioperative administration of low-dose landiolol has a preventive effect on the development of AF after CABG surgery.