Pediatric hematology and oncology
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Pediatr Hematol Oncol · Mar 2019
The impact of severe late-effects after 12 Gy fractionated total body irradiation and allogeneic stem cell transplantation for childhood leukemia (1988-2010).
This study consists of a retrospective study including 71 childhood leukemia survivors (36 females) treated with allo-HSCT 12 Gy fractionated total body irradiation (fTBI) conditioning, with a median age of 25.0 y at time of follow-up and a median delay of 14.8 y since the graft. The recovery ratio was 90%. ⋯ Two-thirds had at least 2 late-effects. These results emphasize the urgent abandonment of conditioning by TBI in children.