Human reproduction
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Review Meta Analysis
Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review.
The object of this review was to compare metformin versus oral contraceptive pill (OCP) treatment in polycystic ovary syndrome. ⋯ The limited RCT evidence to date does not show adverse metabolic risk with the use of the OCP compared with metformin. Further long-term RCTs are required.
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Randomized Controlled Trial
Lidocaine-prilocaine (EMLA) cream as analgesia for hysterosalpingography: a prospective, randomized, controlled, double blinded study.
The aim of our study is to evaluate the efficacy of applying lidocaine 25 mg-prilocaine-25 mg/G cream (EMLA 5%) on the uterine cervix for pain relief when performing hysterosalpingography (HSG). ⋯ Topical application of EMLA 5% cream on the uterine cervix before performing HSG significantly reduced the pain during this procedure.
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Comparative Study
Testing of nine different xeno-free culture media for human embryonic stem cell cultures.
Human embryonic stem cells (hESC) are excellent candidates for cell replacement therapies. However, currently used culture conditions contain animal-derived components that bear a risk of transmitting animal pathogens and incorporation of non-human immunogenic molecules to hESC. ⋯ None of the studied xeno-free media was able to maintain the undifferentiated growth of hESC. The medium containing 20% human serum was found to sustain undifferentiated hESC proliferation to some extent, yet was inferior to the conventional ko-SR-containing medium.