Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Randomized Controlled Trial Clinical Trial
Secondary hyperalgesia is not affected by wound infiltration with bupivacaine.
The purpose of this study was to determine the effects of wound infiltration with bupivacaine on incisional pain and the zone of secondary hyperalgesia. Twenty-eight healthy parturients were studied in a double-blind randomized trial. At the time of Caesarean section one wound edge was infiltrated with saline 0.9% and the other with bupivacaine 0.25%. ⋯ The zone of secondary pain was similar overall for both sides of the wound. It is concluded that the bupivacaine-infiltrated side of the wound was less painful than the saline-injected side 24 hr postoperatively. The zone of pain measured around the wound edges was unaffected by bupivacaine or saline.
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Randomized Controlled Trial Clinical Trial
Orbicular muscle akinesia in regional ophthalmic anaesthesia with pH-adjusted bupivacaine: effects of hyaluronidase and epinephrine.
The success rate and duration of lid akinesia after adding hyaluronidase and/or epinephrine to pH-adjusted bupivacaine was examined in a double-blind fashion in patients undergoing cataract surgery under local anaesthesia. A two-injection-site technique was used. For globe akinesia all patients (n = 120) received an inferolateral intraconal injection (3 ml) of pH-adjusted bupivacaine 0.75% and hyaluronidase. ⋯ No differences in the success rate or duration of the block among the other groups were seen. The duration of the block was longer in the epinephrine groups than in the two other groups (P < 0.01) and longer in the epinephrine and hyaluronidase group than in the group receiving only hyaluronidase (P < 0.05). We conclude that the best initial results and longest duration of blocks were shown in the groups receiving epinephrine or epinephrine and hyaluronidase.