Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Randomized Controlled Trial
Titrated versus conventional anticoagulation management for thrombin generation in cardiac surgery: a randomized controlled trial.
Optimal heparin titration during cardiopulmonary bypass (CPB) may reduce coagulation system activation and preserve hemostatic function post-CPB. Our objective was to assess if the Heparin Management System (HMS) Plus improves heparin titration, thereby leading to higher thrombin generation post-CPB compared with activated clotting time (ACT)-guided management. ⋯ gov (NCT03347201); first submitted 12 October 2017.