Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Statistical approaches have been developed to detect bias in individual trials, but guidance on how to detect systematic differences at a meta-analytical level is lacking. In this paper, we elucidate whether author bias can be detected in a cohort of randomized trials included in a meta-analysis. ⋯ When combining trial-level data to produce a pooled effect estimate, investigators must consider sources of potential bias. Our results suggest that systematic errors can be detected using meta-regression, although further research is needed to examine the sensitivity of this model. Systematic reviewers will benefit from the availability of methods to guard against the dissemination of results with the potential to mislead decision-making.
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Abstract
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Abstract
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Randomized Controlled Trial
Randomized-controlled trial of parent-led exposure to anesthetic mask to prevent child preoperative anxiety.
To examine the efficacy of parent-directed anesthetic mask exposure and shaping practice to prevent child preoperative anxiety, with a specific focus on timing of exposure. ⋯ Timing of the delivery of mask exposure (i.e., on the day of surgery) to address child preoperative anxiety and induction compliance in the day surgery setting may be an important consideration. The current results inform the integration of this simple, effective strategy into practice.
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Review Meta Analysis
A systematic review of interventions to facilitate extubation in patients difficult-to-wean due to delirium, agitation, or anxiety and a meta-analysis of the effect of dexmedetomidine.
Delirium, agitation, and anxiety may hinder weaning from mechanical ventilation and lead to increased morbidity and healthcare costs. The most appropriate clinical approach to weaning in these contexts remains unclear and challenging to clinicians. The objective of this systematic review was to identify effective and safe interventions to wean patients that are difficult-to-wean from mechanical ventilation due to delirium, agitation, or anxiety. ⋯ This systematic review and meta-analysis provides low quality evidence to suggest the use of dexmedetomidine in patients deemed difficult-to-wean due to agitation, delirium, or anxiety. Insufficient evidence was found regarding other interventions to provide any recommendation.