The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Apr 1991
Randomized Controlled Trial Comparative Study Clinical TrialSuccessful immunization of infants at 6 months of age with high dose Edmonston-Zagreb measles vaccine. Cite Soleil/JHU Project Team.
A group of 2097 Haitian infants 6 to 11 months of age were randomized to receive Schwarz or Edmonston-Zagreb strain measles vaccines containing 10- to 500-fold more vaccine viral particles than standard potency vaccines. No unusual adverse reactions were noted. ⋯ High titer Edmonston-Zagreb vaccine administered at 6 months of age induced antibody concentrations greater than or equal to 200 mIU/ml in 83% of infants by plaque reduction neutralization and 93% of infants by enzyme-linked immunosorbent assay with high rates of antibody persistence at 12 to 24 months of age. The World Health Organization recommends high titer Edmonston-Zagreb measles vaccines for routine use at 6 months of age in areas where measles is an important cause of mortality in young infants.
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Pediatr. Infect. Dis. J. · Apr 1991
Randomized Controlled Trial Clinical TrialPurulent nasal discharge.
Purulent nasal discharge is a common presenting symptom associated with infections of the upper respiratory tract. The most likely diagnoses are uncomplicated viral upper respiratory infections and bacterial sinusitis. Allergy may be an underlying problem in children with sinusitis. Less common considerations are adenoiditis, infections caused by B. pertussis, C. diphtheriae or Treponema pallidum or intranasal structural problems.