The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Jan 2002
Plasma concentrations of defensins and lactoferrin in children with severe sepsis.
We hypothesized that systemic release of endogenous leukocyte-derived polypeptide antimicrobial defensins (polymorphonuclear leukocyte-specific) and lactoferrin (polymorphonuclear leukocyte and epithelial cell derived) occurs in nonneutropenic children with severe sepsis. ⋯ These data suggest that increased circulating defensins and lactoferrin release are dependent in part on neutrophil count and might play a role in host defense in children with severe sepsis.
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Pediatr. Infect. Dis. J. · Jan 2002
Case ReportsOchrobactrum anthropi bacteremia in pediatric oncology patients.
Ochrobactrum anthropi is an emerging pathogen in immunocompromised hosts, particularly in patients with indwelling catheters. We report the characteristics of 14 O. anthropi bacteremic episodes in 11 children with Hickman-type central catheters. Children presented with fever and nonspecific clinical manifestations. Bacteremia was successfully treated with antibiotics, but catheter removal was necessary to achieve cure in four cases.