The Pediatric infectious disease journal
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Relatively few pediatric West Nile virus cases have been recognized in the United States since the virus was first identified in 1999. We reviewed the clinical characteristics of 23 cases in pediatric patients that occurred in California in 2004 to better understand the infection in this population.
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Intussusception, a potentially lethal condition with poorly understood etiology, is the most common cause of acute intestinal obstruction in children younger than 5 years old. In some cases, the condition has been associated with administration of the first licensed rotavirus vaccine, the reassortant rhesus-human tetravalent rotavirus vaccine (RRV-TV; RotaShield). No such association has to date been reported from large phase III safety trials with new rotavirus vaccines. ⋯ There are still gaps in our knowledge of intussusception with respect to its etiology and especially by which mechanisms RRV-TV might have caused it to occur. Data from regions outside Europe showed that rotavirus infection and disease are not associated with intussusception. As new rotavirus vaccines become available for use in Europe, postlicensure surveillance for intussusception is indicated and may be instrumental in further understanding the epidemiology of this condition and in further assessing the safety of future vaccines.
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Pediatr. Infect. Dis. J. · Jan 2006
Comparative StudyImmunogenicity and safety of two doses of tetravalent measles-mumps-rubella-varicella vaccine in healthy children.
Combination vaccines against common childhood diseases are widely used, provide an improved coverage, are more convenient and are more cost-effective than multiple injections. We conducted a study to evaluate the safety and immunogenicity of a combined measles-mumps-rubella-varicella (MMRV) candidate vaccine in comparison with the separate administration of licensed measles-mumps-rubella (MMR; Priorix) and varicella (V; Varilrix) vaccines. ⋯ Administration of 2 doses of the combined MMRV vaccine was as immunogenic and well-tolerated as separate injections of MMR and varicella vaccine.
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Pediatr. Infect. Dis. J. · Jan 2006
Case ReportsNeuroborreliosis with progression from pseudotumor cerebri to aseptic meningitis.
We report a patient with an initial diagnosis of Lyme-associated pseudotumor cerebri who developed cerebrospinal fluid pleocytosis consistent with Lyme meningitis. The case illustrates the importance of considering neuroborreliosis in the differential diagnosis of pseudotumor cerebri and describes the evolution of cerebrospinal fluid findings in this condition.
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Pediatr. Infect. Dis. J. · Jan 2006
Late onset neonatal Gram-negative bacillary infection in Australia and New Zealand: 1992-2002.
Late onset neonatal Gram-negative bacillary infection is a significant cause of morbidity and mortality. ⋯ Gram-negative bacilli remain important causes of late onset neonatal sepsis, especially among very low birth weight infants, and result in a high mortality, particularly with P. aeruginosa infections.