The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Sep 2008
Randomized Controlled Trial Multicenter Study Comparative StudyMicafungin versus liposomal amphotericin B for pediatric patients with invasive candidiasis: substudy of a randomized double-blind trial.
Invasive candidiasis is increasingly prevalent in premature infants and seriously ill children, and pediatric data on available antifungal therapies are lacking. ⋯ Micafungin seems to be similarly effective and as safe as liposomal amphotericin B for the treatment of invasive candidiasis in pediatric patients. (ClinicalTrials.gov number, NCT00106288).
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Pediatr. Infect. Dis. J. · Sep 2008
Review Case ReportsNeonatal meningoencephalitis caused by Bacillus cereus.
The classic organisms associated with central nervous system infection in the neonate are herpes simplex, Listeria monocytogenes, Escherichia coli, and Streptococcus agalactiae; we describe an unusual case of neonatal meningoencephalitis caused by Bacillus cereus.
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Pediatr. Infect. Dis. J. · Sep 2008
Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonate.
Hospitalized neonates are exposed to antibiotic-resistant bacterial pathogens and develop nosocomial infections. Limited data are available regarding the neonatal pharmacokinetics of meropenem, a broad spectrum carbapenem antibiotic. ⋯ MCS based on PPK determinations demonstrated that a meropenem dose of 20 mg/kg every 8 hours should provide adequate therapy for most nosocomial Gram-negative pathogens.