The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Feb 2009
Case ReportsPeripheral neuropathy in an adolescent treated with linezolid.
The increased incidence of methicillin-resistant Staphyloccocus aureus infections may increase linezolid use in children. Peripheral neuropathy is a rare adverse effect of linezolid therapy and is more frequent with prolonged courses. We present an adolescent with peripheral neuropathy after 4 months of linezolid therapy and review the literature related to linezolid-induced neuropathies. Children receiving long-term linezolid therapy should be monitored for neuropathy.
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Pediatr. Infect. Dis. J. · Feb 2009
Intravenous colistimethate (colistin) use in critically ill children without cystic fibrosis.
The increasing frequency of infections caused by multidrug-resistant (MDR) Gram-negative bacteria has led to the reappraisal of colistimethate use. ⋯ Although the small number of included cases precludes any firm conclusions, our study suggests that colistimethate may have a role for the treatment of infections caused by MDR Gram-negative bacteria in critically ill pediatric patients.