The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Mar 2012
Reduction in mycobacterial disease among HIV-infected children in the highly active antiretroviral therapy era (1997-2008).
HIV-infected children are at increased risk of developing mycobacterial disease. The aim of this study was to estimate the change in mycobacterial disease rate in HIV-infected children and adolescents in the highly active antiretroviral therapy (HAART) era. ⋯ The rate of mycobacterial disease decreased among HIV-infected children in the HAART era, but the incidence of mycobacterial disease still remains higher than in the general population.
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Pediatr. Infect. Dis. J. · Mar 2012
Characteristics, therapies, and outcome of children with necrotizing soft tissue infections.
Necrotizing soft tissue infections (NSTIs) are uncommon but potentially lethal infections that are well described in adults. Little is known about pediatric patients with NSTI. We sought to examine patients' characteristics, infection characteristics, treatment patterns, and outcomes of children with NSTIs using a large multicenter pediatric database. ⋯ NSTIs are a rare but significant diseases in children. It seems that, as in the adult population, prompt surgical debridement is the most important intervention. Corticosteroid therapy may be associated with a worse prognosis.