The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Oct 2002
Case ReportsFusobacterium osteomyelitis in a child with sickle cell disease.
Children who have sickle cell disease are at increased risk for osteomyelitis caused by Salmonella spp. and Staphylococcus aureus. We report a case of anaerobic osteomyelitis caused by Fusobacterium nucleatum in a child with sickle cell disease. The infection did not resolve with antibiotic therapy alone, but was cured after surgical debridement and hyperbaric oxygen therapy.
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A case of purulent spinal epidural abscess in a 20-day-old girl is presented. The patient had symptoms of fever, localized back pain and swelling over the interscapular area. ⋯ Because of severe cord compression surgical laminotomy and drainage were performed, and antibiotics were administered. One year later she was doing well without neurologic sequelae.
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Pediatr. Infect. Dis. J. · Jul 2002
Review Case ReportsChromobacterium violaceum infection in children: a case of fatal septicemia with nasopharyngeal abscess and literature review.
This previously healthy 5-year-old boy initially presented with fever and purulent conjunctivitis. The course evolved rapidly into preseptal and facial cellulitis, nasopharyngeal abscess and sepsis. ⋯ He received intravenous cefazolin therapy for 2 days, followed by penicillin, oxacillin and netilmicin. However, no improvement was noted, and he died on the fifth days of illness.
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Pediatr. Infect. Dis. J. · Jul 2002
Comparative StudyResponse to changes in antiretroviral therapy after genotyping in human immunodeficiency virus-infected children.
HIV genotyping has been beneficial when choosing salvage regimens in adults failing highly active antiretroviral therapy (HAART). Our objectives were to evaluate the usefulness of genotyping in HIVinfected children failing HAART and to determine whether the presence of resistance mutations was associated with previous antiretroviral therapy. ⋯ This study did not demonstrate substantial clinical benefit to HIV genotyping in antiretroviral agent-experienced pediatric patients with high viral loads. These results contrast with favorable short term clinical and virologic responses to therapeutic changes after genotyping in HIV-infected adults. However, medication history alone does not appear to be an adequate alternative to genotyping in choosing salvage regimens in antiretroviral agent-experienced children.