The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Apr 1991
Randomized Controlled Trial Comparative Study Clinical TrialSuccessful immunization of infants at 6 months of age with high dose Edmonston-Zagreb measles vaccine. Cite Soleil/JHU Project Team.
A group of 2097 Haitian infants 6 to 11 months of age were randomized to receive Schwarz or Edmonston-Zagreb strain measles vaccines containing 10- to 500-fold more vaccine viral particles than standard potency vaccines. No unusual adverse reactions were noted. ⋯ High titer Edmonston-Zagreb vaccine administered at 6 months of age induced antibody concentrations greater than or equal to 200 mIU/ml in 83% of infants by plaque reduction neutralization and 93% of infants by enzyme-linked immunosorbent assay with high rates of antibody persistence at 12 to 24 months of age. The World Health Organization recommends high titer Edmonston-Zagreb measles vaccines for routine use at 6 months of age in areas where measles is an important cause of mortality in young infants.
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Pediatr. Infect. Dis. J. · Apr 1991
Randomized Controlled Trial Clinical TrialPurulent nasal discharge.
Purulent nasal discharge is a common presenting symptom associated with infections of the upper respiratory tract. The most likely diagnoses are uncomplicated viral upper respiratory infections and bacterial sinusitis. Allergy may be an underlying problem in children with sinusitis. Less common considerations are adenoiditis, infections caused by B. pertussis, C. diphtheriae or Treponema pallidum or intranasal structural problems.
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Pediatr. Infect. Dis. J. · Dec 1990
Changes in the differential white blood cell count in screening for group B streptococcal sepsis.
We compared several previously defined scoring systems using white blood cell indices as part of a retrospective evaluation of infants with early onset Group B streptococcal (GBS) sepsis. Nineteen newborns were diagnosed with GBS sepsis between January, 1988, and April, 1990. Case controls (n = 33) were selected from patients admitted to the Neonatal Intensive Care Unit for suspected sepsis. ⋯ Scoring systems for neonatal sepsis by Manroe et al., Rodwell et al. and Spector et al. had poor sensitivity, specificity, positive predictive value and negative predictive value when initial white blood cell count criteria were used, but scoring systems by Manroe and Rodwell were 100% sensitive and had 100% negative predictive value when applied to the repeat white blood cell count. We conclude that a single early complete blood count may not be an adequate screening tool for early onset GBS sepsis and should not be used to rule out infection. Optimal screening for GBS sepsis requires a repeat complete blood count within the first 24 hours of age.