The Pediatric infectious disease journal
-
Pediatr. Infect. Dis. J. · Mar 2010
Predicting severe bacterial infections in well-appearing febrile neonates: laboratory markers accuracy and duration of fever.
To assess the diagnostic accuracy of white blood cell count (WBC), absolute neutrophil count (ANC), and C-reactive protein (CRP) in detecting severe bacterial infections (SBI) in well-appearing neonates with early onset fever without source (FWS) and in relation to fever duration. ⋯ In well-appearing neonates with early onset FWS, laboratory markers are more accurate and reliable predictors of SBI when performed after >12 hours of fever duration. ANC and especially CRP resulted better markers than the traditionally recommended WBC.
-
Pediatr. Infect. Dis. J. · Feb 2010
Randomized Controlled TrialSafety and immunogenicity of trivalent inactivated influenza vaccine in infants: a randomized double-blind placebo-controlled study.
Infants less than 6 months of age are at high risk for influenza disease and influenza-related complications, but no vaccine is licensed for this population. ⋯ TIV administered to young infants beginning at 6 to 12 weeks of age is safe and immunogenic.
-
Pediatr. Infect. Dis. J. · Feb 2010
Randomized Controlled TrialClinical trial and post-licensure safety profile of a prophylactic human papillomavirus (types 6, 11, 16, and 18) l1 virus-like particle vaccine.
We describe the safety of the human papillomavirus (HPV)-6/11/16/18 vaccine using updated clinical trial data (median follow-up time of 3.6 years) and summarize up to 3 years of post-licensure surveillance. ⋯ HPV-6/11/16/18 vaccination was associated with more injection-site pain than placebo but similar incidences of systemic and serious AEs and new medical conditions potentially consistent with autoimmune phenomena. Based on review of post-licensure safety information, the benefits of vaccination to prevent the majority of genital tract precancers and cancers continue to far outweigh its risks.
-
Pediatr. Infect. Dis. J. · Feb 2010
Comment Letter Case ReportsCongenital babesiosis in a four-week-old female infant.
-
Pediatr. Infect. Dis. J. · Jan 2010
Randomized Controlled Trial Comparative StudyA randomized, double-blind study examining the comparative efficacies and safety of inhaled epinephrine and nasal decongestant in hospitalized infants with acute bronchiolitis.
Optimal treatment of acute bronchiolitis is currently unclear. In a double-blind study, we found no significant differences between inhaled epinephrine and nasal decongestant in hospitalized infants with acute bronchiolitis regarding length of hospitalization, need for oxygen supplementation, or intravenous fluids and clinical score. Nasal decongestant is as effective as inhaled epinephrine in acute bronchiolitis.