The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · Dec 2007
Factors influencing the decision to test young infants for herpes simplex virus infection.
In a nested case-control study of 478 infants < or =90 days of age, one-third of infants undergoing cerebrospinal fluid herpes simplex virus (HSV) testing by polymerase chain reaction were >28 days of age. Recognized factors, such as mode of delivery, were not associated with HSV testing. The factors currently used by physicians in the decision to order this test do not best reflect the likelihood of HSV infection.
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Pediatr. Infect. Dis. J. · Nov 2007
Deficiency of mannose-binding lectin-associated serine protease-2 associated with increased risk of fever and neutropenia in pediatric cancer patients.
Mannose-binding lectin-associated serine protease-2 (MASP-2) is an essential component of the lectin pathway of complement activation. MASP-2 deficiency is common because of genetic polymorphisms, but its impact on susceptibility to infection is largely unknown. The aim of the present study was to determine whether children with cancer and MASP-2 deficiency develop more frequent or more severe episodes of fever and severe chemotherapy-induced neutropenia (FN). ⋯ In this study, MASP-2 deficiency was associated with an increased risk of FN in children treated with chemotherapy for cancer. MASP-2 deficiency represents a novel risk factor for chemotherapy-related infections.
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Pediatr. Infect. Dis. J. · Nov 2007
Randomized Controlled TrialRevaccination with locally-produced vi typhoid polysaccharide vaccine among chinese school-aged children: safety and immunogenicity findings.
To evaluate the safety and immunogenicity of revaccination with locally-produced Vi polysaccharide vaccine 3 years after the first dose in Chinese children aged 9 to 14 years. ⋯ We found that revaccination using the locally produced Vi polysaccharide vaccine among Chinese school-aged children was safe and increased antibody titers. Revaccination can be used to extend the duration of protection provided by Vi polysaccharide vaccine.
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Pediatr. Infect. Dis. J. · Nov 2007
Experience with linezolid therapy in children with osteoarticular infections.
The excellent oral bioavailability and the Gram-positive antimicrobial spectrum make linezolid an attractive antibiotic for treatment of osteoarticular infections. The clinical efficacy of this drug has not been previously evaluated for Gram-positive osteoarticular infections in children. ⋯ Linezolid appears to be useful and well tolerated in step-down therapy or compassionate use for pediatric Gram-positive orthopedic infections. A well-designed prospective comparative study is needed to confirm this observation.
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Pediatr. Infect. Dis. J. · Oct 2007
Randomized Controlled Trial Multicenter Study Comparative StudyComparative study of levofloxacin in the treatment of children with community-acquired pneumonia.
Levofloxacin has established efficacy and safety in the treatment of community-acquired pneumonia (CAP) in adults, and its use as an alternative therapy for children with CAP has been proposed. ⋯ Levofloxacin was as well tolerated and effective as standard-of-care antibiotics for the treatment of CAP in infants and children.