Critical care medicine
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We studied regional blood flow (QR) using radiolabeled microspheres in 12 anesthetized dogs during cardiopulmonary resuscitation (CPR). A circumferential vest and abdominal binder were used with a mechanical ventilator to deliver 30 simultaneous chest compressions and ventilations per minute. When this device was modified to increase aortic pressure (Pao) during compression and the aortic-to-right atrial pressure gradient (Pao-Pra) during relaxation, cerebral and myocardial QR increased significantly. These findings suggest that QR during CPR can be improved by augmenting perfusion-pressure gradients across the cerebral and coronary circulations.
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Critical care medicine · Oct 1984
Effect of Intralipid on measurements of total hemoglobin and oxyhemoglobin in whole blood.
A co-oximeter study of whole blood samples containing Intralipid concentrations of 100 to 2000 mg/dl found that the light-scattering effect was greater at lower hematocrits. The methemoglobin reading was affected the most, and led to erroneous displays of total hemoglobin and percent oxyhemoglobin. The O2-content value, however, was accurate over the entire hematocrit and Intralipid concentration range tested. We suggest that an unexplained high methemoglobin value in whole blood samples from patients receiving Intralipid may reflect a light-scattering problem in the instrument.