Critical care medicine
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Critical care medicine · Nov 1991
Randomized Controlled Trial Multicenter Study Clinical TrialEffect of ibuprofen in patients with severe sepsis: a randomized, double-blind, multicenter study. The Ibuprofen Study Group.
To evaluate the safety and physiologic actions of ibuprofen in patients with severe sepsis. ⋯ Ibuprofen was well tolerated when administered iv and rectally to patients with severe sepsis, although drug absorption was poor with the rectal route. Significant antipyretic effects of ibuprofen were demonstrated. Although an excellent safety profile characterized ibuprofen in this study, the absence of ibuprofen-associated toxicity may have been secondary to poor rectal absorption of the drug. Our results support the continued clinical investigation of ibuprofen in sepsis, using an all-intravenous route of administration.
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Critical care medicine · Nov 1991
Randomized Controlled Trial Clinical TrialEffects of bicarbonate therapy on hemodynamics and tissue oxygenation in patients with lactic acidosis: a prospective, controlled clinical study.
To determine whether correction of acidemia using bicarbonate improves hemodynamic variables and tissue oxygenation in patients with lactic acidosis. ⋯ Administration of sodium bicarbonate did not improve hemodynamic variables in patients with lactic acidosis, but did not worsen tissue oxygenation.
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Critical care medicine · Nov 1991
Comparative StudyComparison of oxygen consumption measurements: indirect calorimetry versus the reversed Fick method.
To compare measurement of oxygen consumption (VO2) by spirometry and the reversed Fick method. ⋯ The repeatability of the spirometric method was four times better than the reversed Fick method. The latter gave a significantly lower value that probably, in part, reflects the VO2 of the lung, which is included in the spirometric method but not in the reversed Fick measurement.
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Critical care medicine · Nov 1991
Efficacy of continuous arteriovenous hemofiltration with dialysis in patients with renal failure.
To document the efficacy of continuous arteriovenous hemofiltration with dialysis following renal failure, without protein restriction, and to explore the magnitude and clinical applications of total daily urea clearance. ⋯ Continuous arteriovenous hemofiltration with dialysis appears to be effective for the control of blood urea nitrogen and clearance of urea. This modality also permits full protein alimentation. Total daily urea clearance can be calculated easily and may have important clinical uses and implications.
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Critical care medicine · Nov 1991
Effect of vasoactive treatment on the relationship between mixed venous and regional oxygen saturation.
To evaluate the relationship between the mixed venous (SvO2), hepatic, and femoral venous oxygen saturations before and during sympathomimetic drug infusions. ⋯ The individual values of SvO2 have no predictive value concerning regional oxygen transport. The parallel increase in SvO2 and hepatic venous oxygen saturation suggests that the vasoactive treatment did not compromise splanchnic oxygenation.