Critical care medicine
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Critical care medicine · Feb 1991
Comparative Study Clinical Trial Controlled Clinical TrialImproved outcomes from tertiary center pediatric intensive care: a statewide comparison of tertiary and nontertiary care facilities.
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Critical care medicine · Feb 1991
Comparative Study Clinical Trial Controlled Clinical TrialClinical evaluation of closed-loop control of blood pressure in seriously ill patients.
To compare the effectiveness of a new method of closed-loop (automatic) control of BP with usual manual control. ⋯ The new closed-loop system is more effective than the usual manual control in managing acute BP disturbances in the seriously ill patient.
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Critical care medicine · Feb 1991
Mortality prediction models in intensive care: acute physiology and chronic health evaluation II and mortality prediction model compared.
To compare the Acute Physiology and Chronic Health Evaluation (APACHE II) score with the Mortality Prediction Model (MPM). ⋯ Our investigation indicates that both APACHE II and MPM are good predictors of hospital outcome in our population, but the level of intensive care services received before conventional ICU admission modifies accuracy of predictive models. In any study of outcome using comparative studies of classification systems, confounding biases should be measured.
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Critical care medicine · Feb 1991
Systemic and muscle oxygen uptake/delivery after dopexamine infusion in endotoxic dogs.
This study was designed to test whether dopexamine, a dopaminergic and beta 2-adrenergic agonist, would a) increase systemic oxygen delivery (DO2) in endotoxic dogs, and b) interfere with the ability of resting skeletal muscle to extract oxygen. There were three treatment groups (n = 6 in each group): control, endotoxin alone (E) 4 mg/kg iv, and endotoxin + dopexamine (E + D) 12 micrograms/kg.min. Data were analyzed between and within groups by split-plot analysis of variance with significance of identified differences tested post hoc by Duncan's multiple range test. Donor RBC and dextran were used after endotoxin to maintain adequate perfusion pressures, with Hct kept near 40%. Blood flow to left hindlimb muscles was decreased in controlled steps of 15 min each after stabilization. ⋯ Dopexamine provided hemodynamic support for endotoxic dogs, thereby increasing total DO2 and VO2, while not altering oxygen extraction in the muscle.