Critical care medicine
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Critical care medicine · Jun 1992
Randomized Controlled Trial Comparative Study Clinical TrialReversal of midazolam sedation with flumazenil.
To demonstrate the efficacy of flumazenil in reversing the sedative action of midazolam in ventilated intensive care patients. ⋯ Flumazenil in a dose of 0.15 mg is a safe drug that reverses the sedative effect of midazolam.
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Critical care medicine · Jun 1992
Comparative StudyRelationship between hepatic blood flow and tissue lipid peroxidation in the early postburn period.
To determine the effect of a body burn on effective or nutrient liver blood flow and the relationship between blood flow and oxidant-induced lipid peroxidation. ⋯ Effective liver blood flow is markedly decreased after burn injury, even with apparently adequate volume resuscitation, when using lactated Ringer's solution. Liver lipid peroxidation persists even when effective liver blood flow is maintained, indicating that the oxidant process is not solely related to blood flow. Infusion of the antioxidant deferoxamine during resuscitation not only prevents the lipid peroxidation, most likely by a nonblood-flow-related process, but also results in an increase in blood flow above normal rates, suggesting that postburn liver oxygen needs exceed normal values.
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Critical care medicine · Jun 1992
Outcome of intensive care of the "oldest-old" critically ill patients.
To determine the short-term and long-term outcome of critically ill "oldest-old" (greater than or equal to 85 yrs) patients. ⋯ These findings suggest that age alone may be an inappropriate criterion for allocation of ICU resources.
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Critical care medicine · Jun 1992
Review Practice Guideline GuidelineAmerican College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis.
To define the terms "sepsis" and "organ failure" in a precise manner. ⋯ The use of these terms and techniques should assist clinicians and researchers who deal with sepsis and its sequelae.
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Critical care medicine · Jun 1992
Comparative StudyIndirect calorimetry in mechanically ventilated infants and children: measurement accuracy with absence of audible airleak.
To establish the effect of an audible airleak (around an endotracheal tube) on oxygen consumption (VO2) measurements in pediatric ICU patients. ⋯ These data suggest that if no audible airleak is detected, VO2 determined by indirect calorimetry may be reliably measured in infants and children with a noncuffed endotracheal tube.