Critical care medicine
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Critical care medicine · Jan 2004
Letter Comparative StudyAcute management of severe traumatic brain injury.
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Critical care medicine · Jan 2004
Editorial Comment Comparative StudyHow relaxed should we be with acute respiratory distress syndrome?
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Critical care medicine · Jan 2004
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialMultiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock.
To assess the safety and efficacy of the nitric oxide synthase inhibitor 546C88 in patients with septic shock. The predefined primary efficacy objective was survival at day 28. ⋯ In this study, the nonselective nitric oxide synthase inhibitor 546C88 increased mortality in patients with septic shock.
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Critical care medicine · Jan 2004
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialAdministration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).
To assess the safety and efficacy of the nitric oxide synthase inhibitor 546C88 in patients with septic shock. The predefined primary efficacy objective was resolution of shock, defined as a mean arterial pressure > or =70 mm Hg in the absence of both conventional vasopressors and study drug, determined at the end of the 72-hr treatment period. ⋯ In this study, treatment with the nitric oxide synthase inhibitor 546C88 promoted the resolution of shock in patients with severe sepsis. This was associated with an acceptable overall safety profile.
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Critical care medicine · Jan 2004
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialEffect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome.
To evaluate the effects of a 48-hr neuromuscular blocking agents (NMBA) infusion on gas exchange over a 120-hr time period in patients with acute respiratory distress syndrome. ⋯ Use of NMBA during a 48-hr period in patients with acute respiratory distress syndrome is associated with a sustained improvement in oxygenation.