Critical care medicine
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Critical care medicine · Aug 2010
Randomized Controlled Trial Multicenter Study Comparative StudyA randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis.
To evaluate whether TAK-242, a small-molecule inhibitor of Toll-like receptor-4-mediated signaling, suppresses cytokine levels and improves 28-day all-cause mortality rates in patients with severe sepsis. ⋯ TAK-242 failed to suppress cytokine levels in patients with sepsis and shock or respiratory failure. Treatment with TAK-242 resulted in mild increases in serum methemoglobin levels but was otherwise well tolerated. Although observed mortality rates in patients with both shock and respiratory failure were lower with the 2.4 mg/kg/day dose, differences were not significant.