Critical care medicine
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Critical care medicine · May 2012
Multicenter StudyCritical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States.
The contribution of bacterial coinfection to critical illness associated with 2009 influenza A virus infection remains uncertain. The objective of this study was to determine whether bacterial coinfection increased the morbidity and mortality of 2009 influenza A. ⋯ Among intensive care unit patients with 2009 influenza A, bacterial coinfection diagnosed within 72 hrs of admission, especially with Staphylococcus aureus, was associated with significantly higher morbidity and mortality.
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Critical care medicine · May 2012
Multicenter StudyEvaluating the use of recombinant human activated protein C in adult severe sepsis: results of the Surviving Sepsis Campaign.
The Surviving Sepsis Campaign developed guidelines for the administration of recombinant human activated protein C in adult severe sepsis. However, it is not clear how these impacted clinical practice or patient outcome. ⋯ Recombinant human activated protein C use was associated with a significant improvement in hospital mortality in patients who participated in the Surviving Sepsis Campaign.
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Critical care medicine · May 2012
Multicenter StudyRelationship between neighborhood poverty rate and bloodstream infections in the critically ill.
Poverty is associated with increased risk of chronic illness, but its contribution to bloodstream infections is not well-defined. ⋯ Within the limitations of our study design, increased neighborhood poverty rate, a proxy for decreased socioeconomic status, appears to be associated with risk of bloodstream infection among patients who receive critical care.