Critical care medicine
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Critical care medicine · Nov 2014
Editorial CommentNumber needed to treat-to get clinicians' attention*.
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Critical care medicine · Nov 2014
Comparative StudyDeficiency of the Two-Pore-Domain Potassium Channel TREK-1 Promotes Hyperoxia-Induced Lung Injury.
We previously reported the expression of the two-pore-domain K channel TREK-1 in lung epithelial cells and proposed a role for this channel in the regulation of alveolar epithelial cytokine secretion. In this study, we focused on investigating the role of TREK-1 in vivo in the development of hyperoxia-induced lung injury. ⋯ TREK-1 deficiency resulted in increased sensitivity of lungs to hyperoxia, but this effect is less prominent if overwhelming injury is induced by the combination of hyperoxia and injurious mechanical ventilation. TREK-1 may constitute a new potential target for the development of novel treatment strategies against hyperoxia-induced lung injury.
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Critical care medicine · Nov 2014
Editorial CommentThe pendulum of corticosteroids in sepsis swings again?*.