Critical care medicine
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Critical care medicine · Jun 2014
Acute Insulin Resistance Mediated by Advanced Glycation Endproducts in Severely Burned Rats.
Hyperglycemia often occurs in severe burns; however, the underlying mechanisms and importance of managing postburn hyperglycemia are not well recognized. This study was designed to investigate the dynamic changes of postburn hyperglycemia and the underlying mechanisms and to evaluate whether early glycemic control is beneficial in severe burns. ⋯ These findings suggest that severe burn-induced insulin resistance is partly at least mediated by serum advanced glycation endproducts and positively correlated with mortality. Early glycemic control with insulin or inhibition of advanced glycation endproducts with soluble form of receptor for advanced glycation endproducts ameliorates postburn insulin resistance.
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Critical care medicine · Jun 2014
Editorial CommentRemote inflammatory and metabolic impact of acute injury*.
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Critical care medicine · Jun 2014
Multicenter Study Observational StudyArterial Blood Gas Tensions After Resuscitation From Out-of-Hospital Cardiac Arrest: Associations With Long-Term Neurological Outcome.
In patients resuscitated after out-of-hospital cardiac arrest, mean 24 hour PaCO2 predicted good outcome, specifically time spent with PaCO2 > 45 mmHg. No similar associations could be found between mean 24 h PaO2 and outcome.
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Critical care medicine · Jun 2014
Clinical TrialConservative Oxygen Therapy in Mechanically Ventilated Patients: A Pilot Before-and-After Trial.
To assess the feasibility and safety of a conservative approach to oxygen therapy in mechanically ventilated ICU patients. ⋯ Conservative oxygen therapy in mechanically ventilated ICU patients was feasible and free of adverse biochemical, physiological, or clinical outcomes while allowing a marked decrease in excess oxygen exposure. Our study supports the safety and feasibility of future pilot randomized controlled trials of conventional compared with conservative oxygen therapy.