Critical care medicine
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Critical care medicine · Oct 2015
Randomized Controlled Trial Multicenter StudyDelayed Emergency Team Calls and Associated Hospital Mortality: A Multicenter Study.
We tested the hypothesis that responses to physiologic deterioration in hospital ward patients delayed by more than 15 minutes are associated with increased mortality. ⋯ Among ward patients, emergency team activation in response to acute deterioration triggered more than 15 minutes after detection and documentation of instability is independently associated with an increased risk of ICU admission and death.
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Critical care medicine · Oct 2015
Cortical and Medullary Tissue Perfusion and Oxygenation in Experimental Septic Acute Kidney Injury.
To determine whether there is a decrease in renal cortical or medullary perfusion and oxygenation in a conscious large animal model of hyperdynamic septic shock with acute kidney injury. ⋯ In a large animal model of hyperdynamic sepsis, renal hyperemia was associated with preserved cortical oxygenation and perfusion, but decreased medullary oxygenation and perfusion. Medullary hypoxia due to intrarenal blood flow redistribution may be one of the factors causing acute kidney injury in sepsis.
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Critical care medicine · Oct 2015
Comparative StudyHypothermic Total Liquid Ventilation Is Highly Protective Through Cerebral Hemodynamic Preservation and Sepsis-Like Mitigation After Asphyxial Cardiac Arrest.
Total liquid ventilation provides ultrafast and potently neuro- and cardioprotective cooling after shockable cardiac arrest and myocardial infarction in animals. Our goal was to decipher the effect of hypothermic total liquid ventilation on the systemic and cerebral response to asphyxial cardiac arrest using an original pressure- and volume-controlled ventilation strategy in rabbits. ⋯ Ultrafast cooling by total liquid ventilation limits the post-cardiac arrest syndrome after asphyxial cardiac arrest in rabbits. This protection involves an early limitation in reactive oxidative species production, blood-brain barrier disruption, and delayed preservation against the systemic inflammatory response.
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Critical care medicine · Oct 2015
Observational StudyCirculating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis.
To investigate the impact of circulating histones on cardiac injury and dysfunction in a murine model and patients with sepsis. ⋯ Circulating histones are novel and important mediators of septic cardiomyopathy, which can potentially be utilized for prognostic and therapeutic purposes.