Critical care medicine
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Critical care medicine · Sep 2021
Observational StudySkeletal Muscle Changes, Function, and Health-Related Quality of Life in Survivors of Pediatric Critical Illness.
To describe functional and skeletal muscle changes observed during pediatric critical illness and recovery and their association with health-related quality of life. ⋯ Muscle decreased in critically ill children, which was associated with energy inadequacy and impaired muscle growth postdischarge. Muscle changes correlated with change in mobility, which was associated with child health-related quality of life. Mobility, child health-related quality of life, and parental health-related quality of life appeared to be interlinked.
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Critical care medicine · Sep 2021
Mitochondria-Rich Fraction Isolated From Mesenchymal Stromal Cells Reduces Lung and Distal Organ Injury in Experimental Sepsis.
To ascertain whether systemic administration of mitochondria-rich fraction isolated from mesenchymal stromal cells would reduce lung, kidney, and liver injury in experimental sepsis. ⋯ Mitotherapy decreased lung, liver, and kidney injury and increased survival rate in cecal ligation and puncture-induced sepsis.
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Critical care medicine · Sep 2021
Multicenter Study Observational StudyOutcomes, Time-Trends, and Factors Associated With Ancillary Study Use for the Determination of Brain Death.
Brain death determination often requires ancillary studies when clinical determination cannot be fully or safely completed. We aimed to analyze the results of ancillary studies, the factors associated with ancillary study performance, and the changes over time in number of studies performed at an academic health system. ⋯ A large number of ancillary studies were performed despite a clinical determination of brain death; patients with hypoxic-ischemic brain injury are more likely to undergo ancillary studies for brain death determination, and neurologists were less likely to use ancillary studies for brain death. Recently, the use of electroencephalograms for brain death determination has decreased, likely reflecting significant concerns regarding its validity and reliability.
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Critical care medicine · Sep 2021
Historical ArticleCardiopulmonary Resuscitation and Rescue Therapies.
The history of cardiopulmonary resuscitation and the Society of Critical Care Medicine have much in common, as many of the founders of the Society of Critical Care Medicine focused on understanding and improving outcomes from cardiac arrest. We review the history, the current, and future state of cardiopulmonary resuscitation.