Critical care medicine
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Critical care medicine · Jul 2024
Multicenter StudyOne-Year Recovery Among Survivors of Prolonged Severe COVID-19: A National Multicenter Cohort.
Understanding the long-term effects of severe COVID-19 illness on survivors is essential for effective pandemic recovery planning. Therefore, we investigated impairments among hospitalized adults discharged to long-term acute care hospitals (LTACHs) for prolonged severe COVID-19 illness who survived 1 year. ⋯ Nearly two-thirds of survivors of among the most prolonged severe COVID-19 illness had persistent impairments at 1 year that resembled post-intensive care syndrome after critical illness plus debility from hospital-acquired complications.
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Critical care medicine · Jul 2024
Meta AnalysisAntipsychotics in the Treatment of Delirium in Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
To conduct a systematic review and meta-analysis assessing whether the use of antipsychotic medications in critically ill adult patients with delirium impacts patient-important outcomes. ⋯ In conclusion, our systematic review and meta-analysis demonstrated with moderate certainty that there is no difference in delirium- or coma-free days when delirious critically ill adults are treated with antipsychotic medications. Further studies in the subset of patients with hyperactive delirium may be of benefit.
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Critical care medicine · Jul 2024
Multicenter StudyReal-World Implications of Updated Surviving Sepsis Campaign Antibiotic Timing Recommendations.
To evaluate real-world implications of updated Surviving Sepsis Campaign (SSC) recommendations for antibiotic timing. ⋯ These data support recently updated SSC recommendations to align antibiotic timing targets with risk and probability stratifications. Our results provide empirical support that clinicians and hospitals should not be held to 1-hour targets for patients without shock and with only possible sepsis.
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Critical care medicine · Jul 2024
Multicenter StudyAnalgesia and Sedation Use During Noninvasive Ventilation for Acute Respiratory Failure.
To describe U.S. practice regarding administration of sedation and analgesia to patients on noninvasive ventilation (NIV) for acute respiratory failure (ARF) and to determine the association of this practice with odds of intubation or death. ⋯ The use of sedation and analgesia during NIV is common. Medication exposure was associated with increased odds of intubation or death. Further investigation is needed to confirm this finding and determine whether any subpopulations are especially harmed by this practice.